Introduction

Chronic diabetic wounds represent one of the most serious complications of diabetes mellitus, often leading to infection, delayed healing, tissue necrosis, and in severe cases, limb amputation. Conventional treatments rely heavily on antibiotics, chemical disinfectants, and frequent dressing changes, which may be ineffective against resistant microorganisms and can damage healthy tissues.

To address these challenges, Technofest has developed an advanced wound healing device based on Nano-Titanium Plasma Technology, offering a non-invasive, chemical-free, and highly effective medical solution for the treatment of diabetic foot ulcers and chronic wounds.

Technology Overview

The system operates using cold plasma generated through a nano-titanium–based plasma source, producing controlled levels of reactive oxygen and nitrogen species (RONS). These bioactive agents play a critical role in microbial inactivation and tissue regeneration while remaining safe for human cells.

Key technological features include:

• Nano-Titanium Plasma Generation Module

• Digital Control Panel with Timer and Temperature Regulation

• Automated Dosing System for Ionized Oxygen

• Sterile Sealed Treatment Bag System

• Localized Plasma Delivery via Medical-Grade Hose and Nozzles

The wounded limb is placed inside a sterile disposable bag, allowing plasma ions to circulate directly around the wound area without physical contact, ensuring maximum safety and efficacy.

Medical Mechanism of Action

Plasma therapy supports wound healing through multiple clinically recognized mechanisms:

1. Antimicrobial Activity

Cold plasma effectively inactivates:

• Bacteria (including antibiotic-resistant strains)

• Viruses

• Fungi and spores

This significantly reduces microbial load at the wound site without the use of antibiotics or chemical antiseptics.

2. Stimulation of Tissue Regeneration

Reactive plasma species:

• Enhance fibroblast and keratinocyte activity

• Promote angiogenesis (new blood vessel formation)

• Accelerate collagen synthesis

• Improve oxygen diffusion into ischemic tissues

These effects directly contribute to faster wound closure and tissue repair.

3. Anti-Inflammatory Effects

Plasma treatment modulates inflammatory responses by:

• Reducing chronic inflammation

• Supporting balanced cytokine activity

• Creating optimal conditions for natural healing processes

4. Biofilm Disruption

One of the major obstacles in chronic diabetic wounds is microbial biofilm formation. Plasma effectively breaks down biofilms, making the wound environment receptive to healing.

Treatment Procedure

1. The wound area is cleaned according to standard medical protocols.

2. The affected limb is placed inside a sterile single-use treatment bag.

3. The plasma hose is connected, creating a closed and controlled environment.

4. Treatment parameters such as:

   • Time

   • Temperature

   • Ion concentration
     are automatically adjusted via the digital interface.

5. Plasma treatment is applied for a predefined duration, typically without pain or discomfort.

6. No chemical residue remains on the skin after treatment.

Key Advantages of the Nano-Titanium Plasma System

• Chemical-Free & Antibiotic-Free

• Non-Invasive and Painless

• Safe for Healthy Tissue

• Reduces Risk of Amputation

• Effective Against Drug-Resistant Microorganisms

• Minimal Side Effects

• Short Treatment Sessions

• Suitable for Clinical and Home-Care Settings

Clinical and Economic Impact

The system has the potential to:

• Reduce hospitalization time

• Lower healthcare costs associated with chronic wound management

• Improve patient quality of life

• Decrease dependency on long-term antibiotic therapies